Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.
نویسندگان
چکیده
Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of medicinal chemistry
دوره 47 20 شماره
صفحات -
تاریخ انتشار 2004